San Francisco 49ers - Los Angeles Rams Betting Tips, Prediction & Odds

Team 1 Logo LWLLL
15.11.2021 Levi's Stadium 8.15 PM ET
Team 2 Logo LWWWW
-198 1X2 Visit
1X2 Visit
158 1X2 Visit
Best Tip: Los Angeles Rams to win -3.5 -111 Visit 22Bet

San Francisco 49ers vs Los Angeles Rams Betting Tips, Prediction & Odds

The San Francisco 49ers will have a tough job to hold off the local rival Los Angeles Rams who is trying to reach the post season when they meet at Levi’s Stadium in Santa Clara, CA on November 15, 2021.

San Francisco 49ers Stats & Form

San Francisco 49ersThe 49era have underachieved so far this season currently standing at 3-5.

They had a promising start of the season with two away victories in Detroit and Philadelphia but went on four-game losing streak after that. They stopped the bleeding with a win in Chicago but lost the last one, 31-17 against the short-handed Arizona Cardinals.

The 49ers didn’t stood any chance as they went 14-0 down in the first quarter. They lost a pair of fumbles in the first half and struggled defensively against Colt McCoy who hasn’t seen much playing time this season.

Jimmy Garoppolo played well, throwing for 326 yards and two touchdowns, but the Niners never got the running game established. Garoppolo threw a late interception to end any chance for a comeback.

San Francisco 49ers News

The 49ers have lost their first four home games of the season for the first time since 1982 and third time ever. They are only 1-8 at home in the last two seasons. With JaMycal Hasty, Maurice Hurst, Tavon Wilson, Dre Kirkpatrick and Mohamed Sanu out for tonight’s game, that record is about to get even worse.

Los Angeles Rams Stats & Form

Los Angeles RamsThe LA Rams have been terrific this season with a 7-2 record, standing 2nd in NFC West. Things would look even better if they didn’t drop the last one, 28-16 at home to the Tennessee Titans.

The second quarter proved to be decisive as the Titans took that one by 21-0. Matthew Stafford made a couple of bad decisions in 20 seconds span which was the key factor in the match.

Los Angeles, the NFL’s least-penalized team, also got flagged 12 times for 115 yards, the most yards in Sean McVay’s career.

Despite the bad night against the Titans, Stafford has been pretty good this season as he is the only quarterback with nine games with at least 250 yards passing.

Los Angeles Rams News

The Rams are seeing their opportunity to make the postseason and will certainly look to bounce back against the 49ers. Wide receiver Robert Woods has torn his ACL last week and is out for the season. Ben Skowronek, Darious Williams, Von Miller and Dont’e Deayon are questionable for Monday’s night game.

San Francisco 49ers vs Los Angeles Rams Head-to-Head Stats

The 49ers have won the last four against the Rams and 7 of the last 10. The last time the Rams won in San Francisco was back in 2018 by 39-10.

San Francisco 49ers vs Los Angeles Rams Betting Odds


The odds for San Francisco’s fifth consecutive win against the Rams is at 158. The Rams, who are -3.5 points favorite to win this one have -198 odds for a win.

The point margin is set at 49.5.

San Francisco 49ers vs Los Angeles Rams Betting Tips

Despite the recent head-to-head dominance by the 49ers, the Rams are favorite to win this one. They have played much better this season and the Niners terrible home record goes in Rams favor.

It is expected that the Rams will show who the better team is from the very start and that will win by more than 3.5 points.

  • Tip Quote (Home team win): -198 by 22bet
  • Tip Quote (Away team win): 158 by 22bet
  • Expert betting tip: Los Angeles Rams to win -3.5 (-111 by 22bet)